Radiation Therapy (RT) for Parkinson's Disease (PD)

Mayo Clinic

Status

Invitation-only

Conditions

Parkinson's Disease

Treatments

Radiation: Radiation therapy

Study type

Interventional

Funder types

Other

Identifiers

NCT07218952

24-006978

Details and patient eligibility

About

The purpose of this study is to investigate the use of ultra-low, anti-inflammatory doses of radiation therapy (RT) for the treatment of Parkinson's Disease (PD). In this study, the TrueBeam LINAC utilizes a linear accelerator (LINAC) for the delivery of radiation therapy. Dynamic conformal arc (DCA) therapy will be used to deliver a total of five (5) once-a-day radiation treatments (RT) using DaT-SPECT (Dopamine Transporter-Single-Photon Emission Computed Tomography) and MRI imaging to guide radiation treatment planning.

Enrollment

20 estimated patients

Sex

All

Ages

45 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

Age ≥ 45 and ≤ 70 years
Diagnosis of Parkinson's disease by a Movement Disorder Neurologist
Confirmation of unilateral Parkinson's disease by Dopamine Transporter (DaT) scan
A score of 2 or less on the modified Hoehn and Yahr scale
ECOG Performance Status (PS) ≤ 2 (Appendix I).
No known genetic causes or predisposition to Parkinson's disease or related diseases.
Ability to complete questionnaires, neurological exam, and follow-up imaging independently or with assistance
Ability to provide written informed consent
Willing to provide mandatory blood samples for correlative research purposes
Willing to return to enrolling institution for follow-up

Exclusion Criteria

Concomitant dementia diagnosis or concerns of other memory disorder
Parkinson's Disease medication changes within the last 3 months
Receipt of radiation therapy for Parkinson's Disease outside Mayo Clinic, Rochester