Radiofrequency Ablation for Management of Benign/Indeterminate Thyroid Nodules and Low Risk Papillary Thyroid Cancers

M.D. Anderson Cancer Center

Status: Enrolling

Conditions: Low Risk; Radiofrequency Ablation; Papillary Thyroid Cancer

Treatments: Other: Questionnaire

Study type: Observational

Funder types: Other

Identifiers

NCT07140757

2025-0083

NCI-2025-06179 (Other Identifier)

Details and patient eligibility

About

To track the outcomes of patients who have been treated with RFA and its long-term effectiveness, and to learn more about the quality of life of patients who have received RFA in this study.

Full description

Primary Objectives

• To evaluate thyroid nodule volume changes over time in participants undergoing RFA as part of clinical care

Secondary Objectives

• To establish the health-related quality of life among participants undergoing with ultrasound guided RFA.
• To evaluate the sonographic features of thyroid nodules over time following ultrasound guided RFA.
• To assess adverse events rates following ultrasound guided RFA.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Eligibility Criteria

1. Participants scheduled to undergo ultrasound-guided RFA for the following conditions: benign thyroid nodules, indeterminate thyroid nodules, low-risk DTC, and recurrent PTC

2. Participant is over 18 years and is either not a surgical candidate or has declined surgery.

3. Capable and willing to provide written informed consent

4. Participant has one of the following diagnoses:

   • Biopsy-proven benign thyroid nodules causing compressive and/or cosmetic symptoms who are requesting treatment,
   • Biopsy-proven indeterminate nodules (AUS or follicular neoplasm)
   • Papillary thyroid carcinoma (PTC) without metastasis
   • Locally recurrent thyroid cancer (< 2 cm).

Exclusion Criteria

1. Participants meeting any of the following criteria will be excluded:
2. Participants considered unsuitable for RFA by the treating physician