Radiofrquency Ablation Combined With Cytokine-induced Killer Cells for the Patients With Cervical Cancer

Soochow University

Status and phase: Active, not recruiting; Phase 2

Conditions: Cervical Cancer

Treatments: Biological: Cytokine-induced killer cells; Procedure: Radiofrequency ablation

Study type: Interventional

Funder types: Other

Identifiers

NCT02490748

cervical001

Details and patient eligibility

About

The purpose of this study is to determine whether combining of radiofrequency ablation (RFA) and cytokine-induced killer cells (CIK) transfusion can prolong survival of patients with cervical cancer.

Full description

The primary objective is to evaluate whether RFA followed by CIK transfusion can prolong survival of patients with cervical cancer.

Enrollment: 10 patients

Sex: Female

Ages: 30 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• They were systematic reviews based on randomized controlled trials (rcts). They were phase II rcts comparing chemotherapy with other systemic therapy agents or with no further treatment for recurrent, metastatic, or persistent cervical cancer.

they reported at least one of these outcomes: complete or partial response rate, overall or progression-free survival rate, adverse effects, or healthrelated quality of life (rcts reporting on heterogeneous populations-for example, women at a range of disease stages-were included if results were given separately for patients with recurrent, metastatic, or persistent cervical cancer).

Exclusion criteria

• studies evaluating the role of radiotherapy administered with chemotherapy, or second- or subsequent-line therapy options.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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10 participants in 2 patient groups

RFA alone

No Intervention group

Description:

Patients undergo radiofrequency ablation alone.

RFA+CIK

Experimental group

Description:

Autologous cytokine-induced killer cells were transfer via venous one week after RFA Interventions

Treatment:

Procedure: Radiofrequency ablation

Biological: Cytokine-induced killer cells