Radiogenomic and Prognosis Analysis in Glioma

Asan Medical Center

Status

Unknown

Conditions

Glioma

Treatments

Diagnostic Test: MRI

Study type

Observational

Funder types

Other

Identifiers

NCT04122521

AsanMCHSKim_03

Details and patient eligibility

About

This study aims to evaluate whether MRI can be used to predict genomics and prognosis in glioma. Given the profound prognostic significance of genetic mutations seen in glioma, there have been increasing attempts to correlate imaging characteristics with genetic, mutational and expression patterns. To be able to predict genomics and prognosis based on imaging alone will prove useful in patients with involvement of glioma in delicate areas of the brain and better reflect tumor and molecular heterogeneity.

Full description

Previous studies have proposed certain imaging characteristics correlating with genetic, molecular and expression patterns. Advanced imaging provides additional clues but no studies have examined its added value particularly in a prospective setting. The investigator's aim to evaluate preoperative MRI for patients suspected of glioma to predict IDH mutation, 1p19q codeletion, MGMT methylation and EGFR mutation status using imaging characteristics such as margin, patterns of contrast enhancement and edema as well as diffusion and perfusion characteristics. This will be confirmed pathologically and further correlated with patients' long term outcome.

Enrollment

62 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients suspected of glioma undergoing MRI examination prior to surgery
MRI including advanced imaging such as cerebral blood volume, apparent diffusion coefficient and amide proton transfer imaging
Signed informed consent

Exclusion criteria

Pathologic confirmation as tumors other than glioma
Patients who have any type of bioimplant activated by mechanical, electronic, or magnetic means (e.g., cochlear implants, pacemakers, neurostimulators, biostimulates, electronic infusion pumps, etc), because such devices may be displaced or malfunction
Patients who are pregnant or breast feeding; urine pregnancy test will be performed on women of child bearing potential