Radiographic and Histomorphometric Evaluation of Xenograft as a Socket Preservation Material in Maxillary Posterior Teeth.

Suez Canal University

Status: Completed

Conditions: Socket Preservation

Treatments: Device: S1-XB; Procedure: Control (Standard treatment)

Study type: Interventional

Funder types: Other

Identifiers

NCT07250256

547-2022

Details and patient eligibility

About

Radiographic and Histomorphometric Evaluation of Xenograft as a Socket Preservation Material in Maxillary Posterior Teeth: A Randomized-Controlled Clinical Study

Full description

The process of natural healing starts with new bone formation taking place from initial islands of bone within the connective tissue occurring after a 4 to 8 weeks interval from extraction date. This is followed by the manifestation of a mature trabecular structure that can be noticed at 10 to 20 weeks after extraction accompanied with a reduction in osteoblast count. As a result of the extensive bone resorption post extraction, the prosthetically driven implant placement is compromised and in need of some ridge preservation techniques that have been widely studied to try and ensure less alveolar bone loss. The aim of this research is to study the S1-XB Xenograft containing hydrogel and to evaluate its effects on extraction socket healing in comparison to natural socket healing. This is an In-Vivo comparative randomized controlled study that will be conducted on patients of the outpatient clinic of Oral and Maxillofacial department Suez Canal University to evaluate the difference between using S1-XB bone graft as a socket preservation material and normal socket healing without adding any socket preservation materials.

Enrollment: 16 patients

Sex: Male

Ages: 21 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male patients aged between 21 and 40 years.
• General good health.
• Absence of any relevant systemic disease.
• Presence of a hopeless maxillary posterior tooth that requires extraction.
• Extraction site suitable for replacement by a dental implant.
• Cases have adequate bone width and length.
• Volunteer subjects must sign an informed consent.

Exclusion criteria

• Poor oral hygiene with no possibility of improvement.
• Smokers (more than 10 cigarettes per day).
• Chronic treatment with any medication known to affect oral status and bone turnover.
• Drug or alcohol abuse.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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16 participants in 2 patient groups, including a placebo group

Study group

Active Comparator group

Description:

(8 cases): was treated by immediate socket preservation with S1-XB xenograft augmentation after extraction.

Treatment:

Device: S1-XB

Control group

Placebo Comparator group

Description:

(8 cases): was not exposed to any type of socket preservation after the extraction procedure.

Treatment:

Procedure: Control (Standard treatment)