Radiologic Features of Invasive Pulmonary Aspergillosis

Asan Medical Center

Status: Completed

Conditions: Solid Organ Transplantation; Hematologic Disease

Study type: Observational

Funder types: Other

Identifiers

NCT01178177

IPA -HEM vs SOT-2010

Details and patient eligibility

About

Invasive pulmonary aspergillosis (IPA) is an opportunistic infection that primarily affects recipients of solid organ transplants (SOTs) and patients with chemotherapy- induced neutropenia.Although both of these populations are at high risk for IPA, they differ with regards to the specific defects in host defense mechanisms that increase their risk for IPA. Chemotherapy- induced neutropenia is the principal defect affecting patients with hematologic malignancies, whereas transplant recipients tend to have dysfunctional T cells and phagocytes, as a result of immunosuppressive drug therapy. Thus, the patterns of IPA-related infection and inflammation may differ according to the type of underlying immune defect. Although the clinical and radiological features of IPA in patients with neutropenia have been extensively studied, little is known about the characteristics of IPA in SOT recipients. The investigators therefore compared the IPA- related clinical and radiological findings in SOT recipients with those of neutropenic patients.

Enrollment: 130 patients

Sex: All

Ages: 16+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• IPA cases with solid organ transplant recipients and hematologic disease patients
• proven and probable invasive pulmonary aspergillosis by modified EORTC/MSG criteria

Exclusion criteria

• under 16 years old
• possible cases of invasive pulmonary aspergillosis

Trial design

130 participants in 2 patient groups

SOT recipients

Description:

solid organ transplant recipients with invasive pulmonary aspergillosis

Hematologic disease

Description:

Hematologic disease patients with invasive pulmonary aspergillosis