Radiomic Assessment in NSCLC: Correlation Between Multiparametric Imaging Biomarkers and Genetic Biomarkers

Samsung Medical Center

Status: Invitation-only

Conditions: Lung Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT01585545

2012-03-068

Details and patient eligibility

About

The purpose of this study is to evaluate relationships between multiparametric imaging biomarkers and genetic analysis in NSCLC patients.

Full description

To evaluate relationships between multiparametric imaging biomarkers(CT, PET/CT, MRI) and genetic analysis in NSCLC patients

Enrollment: 500 estimated patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Suspected lung cancer on chest CT or histologically proven NSCLC
• Participant is being considered for the conventional/neoadjuvant/targeted chemotherapy or surgery
• At least one measurable primary or other intrathoracic lesion >= 2cm, according to RECIST
• Performance status of 0 to 2 on the ECOG scale
• Age 20 years or older
• Able to tolerable PET/CT and CT imaging required by protocol
• Able to undergo percutaneous needle biopsy before and after chemotherapy
• Able to give study-specific informed consent

Exclusion criteria

• Poorly controlled diabetes
• Contraindication for CT contrast agent

Trial design

500 participants in 1 patient group

patients with NSCLC