Radiomic Modeling in Differentiating Uncomplicated From Complicated Acute Appendicitis

Kecheng Zhang

Status: Enrolling

Conditions: Acute Appendicitis

Treatments: Diagnostic Test: without

Study type: Observational

Funder types: Other

Identifiers

NCT05843630

PLAGH202304

Details and patient eligibility

About

Non-operative management (NOM) with antibiotics may be a safe alternative to surgery for uncomplicated appendicitis, but preoperative differentiation between uncomplicated and complicated appendicitis is challenging. The study aimed to develop a clinical-radiomics nomogram to distinguish uncomplicated from complicated appendicitis.

Enrollment: 250 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pathologically diagnosed as acute appendicitis after appendectomy between January 2021 and December 2022.

Exclusion criteria

• age less than 18 years (no upper age limit);
• without CT examination within a week before surgery;
• difficult to outline the contours of the appendix due to inflammatory exudate;
• lack of clinical information.

Trial design

250 participants in 3 patient groups

Training cohort

Description:

Model construction based on training cohort

Treatment:

Diagnostic Test: without

Validation cohort 1

Description:

Model validation in an independent validation cohort 1

Treatment:

Diagnostic Test: without

Validation cohort 2

Description:

Model validation in an independent validation cohort 2

Treatment:

Diagnostic Test: without