Radiomics Model Based on DCE-MRI and Ultrasound Images for Breast Lesion Classification

Ma Zhe

Status: Completed

Conditions: Breast Diseases

Study type: Observational

Funder types: Other

Identifiers

NCT06497023

YXLL-KY-2024(055)

Details and patient eligibility

About

To develop and compare multi-modality radiomics models based on DCE-MRI, B-mode ultrasound (BMUS) and strain elastography (SE) images for classifying benign and malignant breast lesions.

Full description

In this retrospective study,555 breast lesions from 555 patients who underwent DCE-MRI, BMUS and SE examinations were randomly divided into training (n =388) and testing (n = 167) datasets. Radiomics features were extracted from manually contoured images. The inter-class correlation coefficient (ICC), Mann-Whitney U test and the least absolute shrinkage and selection operator (LASSO) regression was applied for feature selection and radiomics signature building.Nine radiomics models including four single-modality radiomics models (DCE-3D, DCE-2D, BMUS, and SE), four multi-modality radiomics models (BMUS + SE, DCE-3D + BMUS, DCE-3D + SE, and DCE-3D+SE+BMUS), and the combination diagnostic model(clinical features and DCE-3D+SE+BMUS features) were developed and evaluated by their discrimination, calibration, and clinical usefulness.

Enrollment: 550 patients

Sex: Female

Ages: 15 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients with breast lesions underwent biopsy or surgical resection between January 1, 2018 and March 30, 2024.

Exclusion criteria

1. pathologicalresult of biopsy or surgical specimen was unavailable for the target lesion;
2. patients without DCE-MRI, BMUS and SE examinations before biopsy or surgery within one month;
3. patients hadperformed radiotherapy, chemotherapy, or breast biopsy before MRI and ultrasound examinations;
4. patients without completeDICOM data for each examination;
5. patients with poor-qualityimages.

Trial design

550 participants in 2 patient groups

maligant

Description:

female patients with maligant breast masses who underwent biopsy and/or surgical resection.

benign

Description:

female patients with benign breast masses who underwent biopsy and/or surgical resection.