Radiomics Model for the Diagnosis of Pneumocystis Jirovecii Pneumonia in Non-HIV Patients

Chinese PLA General Hospital (301 Hospital)

Status: Active, not recruiting

Conditions: Pneumocystis Jirovecii Pneumonia

Treatments: Diagnostic Test: Radiomic model

Study type: Observational

Funder types: Other

Identifiers

NCT05701631

S2023-006-01

Details and patient eligibility

About

To evaluate the performance of radiomics in differentiating Pneumocystis jirovecii pneumonia (PCP) from other types of pneumonia and to improve the diagnostic efficacy of non-invasive tests in non-HIV patients.

Full description

Retrospective study, including non-HIV patients hospitalized for suspected PCP from January 2010 to December 2022. The included patients were randomized in a 7:3 ratio into training and validation cohorts. Radiomic features were extracted from semi-automatically identified infected areas in computed tomography (CT) scans and used to construct a radiomic model, which was then compared to a clinical-imaging model built with clinical and semantic CT features in terms of diagnostic performance of PCP. The combination of the radiomic model and serum β-D-glucan levels was also evaluated for PCP diagnosis.

Enrollment: 140 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• aged over eighteen years;
• presence of an underlying disease known to be associated with PCP
• symptoms of lower respiratory tract infection, such as fever, cough or dyspnea
• signs of lung infection on high resolution CT at the on-set of the disease
• received BAL examination within three days after CT scans
• underwent qPCR and IF staining tests on the BAL fluid sample.

Exclusion criteria

• with HIV infection
• taking trimethoprim-sulfamethoxazole for prophylaxis
• undiagnosed by qPCR and IF staining tests

Trial design

140 participants in 1 patient group

non-HIV patients hospitalized for suspected PCP

Description:

non-HIV patients hospitalized for suspected PCP

Treatment:

Diagnostic Test: Radiomic model