Radiotherapy Alternates Human Epidermal Growth Factor 2 (Her2) Expression in Human Breast Cancer

Qingdao Central Hospital

Status: Completed

Conditions: Human Epidermal Growth Factor 2 Negative Carcinoma of Breast

Study type: Observational

Funder types: Other

Identifiers

NCT01934478

QCH20130823-2

Details and patient eligibility

About

Based on fundamental study （in Vitro and in Vivo, Pro. Jianjian Li）， Her2 expression would be changed from negative to positive by cancer irradiation with liner-accelerator at dose 6GY or up. The propose of this study is to reveal the irradiation result on Her2 expression in human breast cancer.

Enrollment: 5 patients

Sex: Female

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• histological confirmed advanced breast cancer
• cancer sample can be obtained by fine needle biopsy
• IHC and FISH confirmed Her2 negative
• radiotherapy indication for local residual cancer

Exclusion criteria

• no radiotherapy indication
• patient refuse