Radiotherapy for Malignant Astrocytomas in the Elderly

Assistance Publique - Hôpitaux de Paris

Status and phase: Completed; Phase 3

Conditions: Glioblastoma Multiforme; Anaplastic Astrocytoma; Primary Brain Tumor

Treatments: Drug: Radiotherapy

Study type: Interventional

Funder types: Other

Identifiers

NCT00430911

PHRC, P000502 AOM 98071

Details and patient eligibility

About

A randomized trial comparing radiotherapy with supportive care in patients aged 70 years or older with newly diagnosed, histologically confirmed anaplastic astrocytoma or glioblastoma, and a Karnofsky performance status > 70.

Sex: All

Ages: 70+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Glioblastoma and anaplastic astrocytoma, supratentorial, histologically confirmed
• Brain CT scan or MRI within 28 days before surgery
• Age: 70 years or older
• Karnofsky performance status, 70 or more.
• Life expectancy over 12 weeks
• Informed consent

Exclusion criteria

• Brain radiotherapy
• Chemotherapy
• Severe systemic disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)