Ramosetron OD Tablet and Postdischarge Nausea and Vomiting

Seoul National University

Status and phase: Unknown; Phase 4

Conditions: Day Surgery

Treatments: Drug: Ramosetron

Study type: Interventional

Funder types: Other

Identifiers

NCT04297293

B-2002/594-003

Details and patient eligibility

About

Postoperative nausea and vomiting after general anesthesia is one of the common anesthetic complications. If the patient is discharged from the hospital after surgery, proper treatment may be delayed or impossible if nausea and vomiting occurred. Thus, it is necessary to prevent these symptoms beforehand. Patients who underwent day-surgery will be treated with prophylactic ramosetron orally disintegrating tablets to determine whether the frequency of nausea and vomiting is decreased when the patient returned home after discharge.

Enrollment: 138 estimated patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who undergo day-surgery under general anesthesia and are discharged on the day of surgery

Exclusion criteria

• Pregnancy or breastfeeding
• Patients who are taking other serotonin receptor antagonists
• Patients who have galactose intolerance or Lapp lactase deficiency
• patients who have glucose-galactose malabsorption

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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138 participants in 2 patient groups

Ramosetron-ODT

Experimental group

Treatment:

Drug: Ramosetron

Control

No Intervention group