Randomised Prospective Study of CUSA Versus Radiofrequency Ablation Technique in Liver Resections

Barts & The London NHS Trust

Status: Completed

Conditions: Liver Disease

Treatments: Device: radiofrequency ablation

Study type: Interventional

Funder types: Other

Identifiers

NCT06980571

P3/04/Q0605/31

Details and patient eligibility

About

The purpose of this study is to determine whether a particular method of operating on the liver is superior to the "gold" standard commonest technique. CUSA (ultrasonic agitation) will be compared to the newer heat coagulation technique (radiofrequency ablation) and comparisons of blood loss, transfusion requirements, complication rates, hospital stay, effect on liver function, health economics and death rate will be made. The groups will be assessed for comparability in terms of underlying disease, resection type, underlying concurrent illnesses, sex, age, background liver disease. Standardisations of the rest of the operation will be carried out including anaesthetic technique and fluid requirements will be assessed by oesophageal Doppler. 100 patients will be recruited.

Enrollment: 100 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• any adult patient listed for liver resection giving informed consent

Exclusion criteria

• children, non-consent and diminished responsibility

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Radiofrequency ablation

Active Comparator group

Description:

50 patients randomised to radiofrequency ablation technique of liver resection

Treatment:

Device: radiofrequency ablation

CUSA

No Intervention group

Description:

50 patients having liver resection randomised to CUSA