Randomized Clinical Trial of an Exposure-based Cognitive Therapy for Depression

University of Zurich (UZH)

Status and phase

Unknown

Phase 2

Conditions

Unipolar Depression

Treatments

Behavioral: Exposure-Based Cognitive Therapy for Depression

Behavioral: Cognitive-Behavioral Therapy for Depression

Study type

Interventional

Funder types

Other

Identifiers

NCT01012856

PP00P1_ 123377

Details and patient eligibility

About

The purpose of this study is to investigate, if exposure-based cognitive therapy (EBCT) is at least as effective as the established cognitive-behavioral therapy and more effective in its long-term efficacy. Moreover the mechanisms of change of the EBCT are investigated.

Enrollment

142 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Major Depressive Disorder according to DSM-IV as main diagnosis
minimum standardized depression scores (BDI >= 17; HAMD >=13)
minimum age of 18 years
informed consent to participate voluntarily in the study
sufficient German language skills

Exclusion criteria

acute suicidality
depressive disorder with mood-incongruent psychotic features
chronic depressive disorder
organic cause of depression
drug-induced depression
bipolar disorder
diagnosis of schizophrenia, schizophreniform, schizoaffective disorders, and/or psychosis NOS
comorbid dysthymia, psychotic disorder (acute or anamnestic), dementia, substance dependence, schizotypal/ borderline/ or antisocial personality disorder
psychopharmacological treatment other than antidepressants
antidepressant medication, if it is changed within one month prior to the beginning of psychotherapy
other simultaneous psychological treatments