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Randomized Clinical Trial of Polyester vs. Polyurethane Patch for Carotid Endarterectomy

U

University of Poitiers

Status

Completed

Conditions

Carotid Artery Stenosis
Stroke
Carotid Artery Thrombosis

Treatments

Procedure: CEA

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

This study examines the risk of thrombogenicity of the carotid patches in polyurethane compared to carotid patches in polyester including death, any stroke, carotid thrombosis at 30 days and long-term results including stroke and recurrent carotid stenosis at 10 years.

This study was run at the University of Roma, La Sapienza and at the University of Poitiers, randomisation was done in both enters after approval by the Ethical committee of the University of Roma (Record uploaded)

Full description

This study examines the risk of thrombogenicity of the carotid patches in polyurethane compared to carotid patches in polyester including death, any stroke, carotid thrombosis at 30 days and long-term results including stroke and recurrent carotid stenosis at 10 years.

598 patients were considered for randomisation between January 1995 and January 2004. The following patients were excluded for randomisation (Redo carotid surgery: N=34, radiation induced carotid stenosis:N=45, indication for carotid bypass: N=65, Refusal of randomisation: N=4).

In total, 450 patients were randomized in two groups, 225 received a polyester patch and 225 received a polyurethane patch.

All patients were operated under general anaesthesia and all received an intraoperative angiography. A shunt was selectively used in patients with a recent stroke (<15 days) or with a contralateral carotid occlusion

Enrollment

450 patients

Sex

All

Ages

25 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Carotid stenosis > 60% NASCET criteria

Exclusion criteria

  • Redo carotid surgery
  • Radiation induced carotid stenosis
  • Extensive carotid lesion > 5 cm in length with involvement of the common carotid artery best treated by a carotid bypass

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

450 participants in 2 patient groups

CEA + Polyester patch
Experimental group
Description:
225 Patients
Treatment:
Procedure: CEA
CEA + Patch Polyurethane
Experimental group
Description:
225 Patients
Treatment:
Procedure: CEA

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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