Randomized Comparison of Continuous and Intermittent Heparin Infusion During Catheter Ablation of Atrial Fibrillation (COHERE)

Yong Seog Oh

Status and phase: Completed; Phase 3

Conditions: Coagulation; Intravascular

Treatments: Drug: Intermittent heparin infusion; Drug: Continuous heparin infusion

Study type: Interventional

Funder types: Other

Identifiers

NCT01935557

COHERE

Details and patient eligibility

About

Optimal anticoagulation using heparin with close attention to maintain therapeutic dosing during the procedure is important.

Randomized comparison of continuous and intermittent heparin infusion during catheter ablation of Atrial Fibrillation.

Full description

Intravenous heparin was used during the procedure to prevent catheter-induced thrombosis.

heparin is administered during the procedure to achieve recommended activation clotting times (ACT) values, typically >300 seconds to prevent thromboemboli during the procedure.

Most of the practitioners was that ACT level should be checked at 30- to 60-minute intervals and then have injected intermittently.

intermittent heparin infusion, concentration is great changed because the heparin has 30minutes half-period.

researchers postulate that a constant therapeutic concentrations would be beneficial to continuous infusion than intermittent infusion.

Enrollment: 296 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Atrial Fibrillation, Radiofrequency catheter ablation scheduled

Exclusion criteria

• Clinical trial denied

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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296 participants in 2 patient groups

Continuous heparin infusion group

Active Comparator group

Description:

continuous group is given an initial intravenous heparin 100u/kg and then maintain heparin infusion during procedural.

Treatment:

Drug: Continuous heparin infusion

Intermittent heparin infusion group

Active Comparator group

Description:

Intermittent group is given an initial intravenous heparin 100u/kg. Then The ACT is tested every 30min with administration of additional heparin boluses and titration of the heparin drip based on the results and according to the judgment of the operating physician.

Treatment:

Drug: Intermittent heparin infusion