Randomized, Controlled Study to Investigate the Effect of Neuromuscular Electrical Stimulation (NMES) on Muscle Metabolism of Abdominal Surgical Patients

Medical University of Vienna

Status: Completed

Conditions: Muscular Atrophy

Treatments: Device: neuromuscular electrical stimulation: Cefar-Sport (CefarCompex Scandinavia AB)

Study type: Interventional

Funder types: Other

Identifiers

NCT00635440

Muscle-2446

Details and patient eligibility

About

Skeletal muscle atrophy is associated with catabolic conditions such as major surgical interventions and leads to reduced muscle strength, increased clinical complications and prolonged convalescence. Several studies revealed immobilisation as a major stimulus for muscle wasting in severely ill patients. This study investigates the potency of neuromuscular electrical stimulation on skeletal muscle growth factors and degradation processes in major abdominal surgery patients.

Enrollment: 26 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• intended for major abdominal surgery
• more than 18 years old

Exclusion criteria

• neuromuscular diseases
• immobility before surgery
• arterial occlusive disease Fontaine stadium IV
• clinical or laboratory signs of inflammation or sepsis
• cachexia
• diseases of the musculoskeletal systems contraindicating electrical stimulation

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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26 participants in 2 patient groups

A

Active Comparator group

Treatment:

Device: neuromuscular electrical stimulation: Cefar-Sport (CefarCompex Scandinavia AB)

Device: neuromuscular electrical stimulation: Cefar-Sport (CefarCompex Scandinavia AB)

B

Sham Comparator group

Treatment:

Device: neuromuscular electrical stimulation: Cefar-Sport (CefarCompex Scandinavia AB)

Device: neuromuscular electrical stimulation: Cefar-Sport (CefarCompex Scandinavia AB)