Randomized Controlled Trial of Intravenous Magnesium Sulfate Versus Terbutaline for Children in the Management of Acute Exacerbation of Asthma

Muhammad Aamir Latif

Status and phase: Completed; Phase 3

Conditions: Acute Exacerbation of Asthma

Treatments: Drug: Terbutaline Infusion; Drug: Magnesium Sulphate infusion

Study type: Interventional

Funder types: Other

Identifiers

NCT06626620

NISHTARASTHMASTUDY

Details and patient eligibility

About

This study aimed to fill this gap by comparing the effectiveness of intravenous magnesium sulfate versus terbutaline in children with acute asthma exacerbations, providing evidence-based guidance for clinicians in emergency settings.

Full description

Despite the established roles of both magnesium sulfate and terbutaline in the management of severe asthma exacerbations, there is limited comparative data on their efficacy and safety in the pediatric population. Understanding the relative benefits and risks of these therapies is crucial for optimizing treatment strategies and improving patient outcomes.

Enrollment: 120 patients

Sex: All

Ages: 5 to 12 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Known cases of asthma
• Minimum duration of asthma as 6 months
• Presenting with acute exacerbation of asthma
• Requiring emergency treatment.

Exclusion criteria

• Children having chronic respiratory diseases (cystic fibrosis, bronchopuonary dysplasia)
• Children with cardiac diseases
• Children who were hospitalized in the past 2-weeks due to any reasons
• Children using oral or intravenous corticosteroids or other systemic medications
• Children who were unable to undergo PEFR measurements due to any reasons

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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120 participants in 2 patient groups

IV Magnesium Sulfate

Experimental group

Description:

Magnesium sulfate, a smooth muscle relaxant, has been shown to have bronchodilatory effects by inhibiting calcium influx into smooth muscle cells.

Treatment:

Drug: Magnesium Sulphate infusion

IV Terbutaline

Experimental group

Description:

Terbutaline, a beta-2 agonist, is used intravenously to provide systemic bronchodilation when inhaled bronchodilators are not effective.

Treatment:

Drug: Terbutaline Infusion