Randomized Phase III-Study in Stage IIIb and IV Non-Small-Cell Lung Cancer. Sequential Single-Agent vs. Double-Agent vs. Triple-Agent Therapy.

A

Aktion Bronchialkarzinom e.V.

Status and phase

Completed
Phase 3

Conditions

Non-Small-Cell Lung Carcinoma

Treatments

Drug: Navelbine
Drug: Gemcitabine
Drug: Cisplatin
Drug: Carboplatin
Drug: Ifosfamide
Drug: Mitomycin

Study type

Interventional

Funder types

Other

Identifiers

NCT00148395
NSCLC 06/2001

Details and patient eligibility

About

This study wants to assess different intensive therapy sequences for the treatment of non-small-cell lung cancer. It claims less on the efficacy of different chemotherapy combinations, than more on the comparison of different strategies of sequential single-agent, sequential double-agent or sequential triple-agent therapy.

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Histological verified non-small cell lung cancer. Cytological diagnosis is accepted for doubtless results.
  • Present stage IIIb with malignant pleural effusion or stage IV disease. Tumor dissemination should not be irradiable in one field
  • Age between 18 and 75 years
  • Karnofsky index 70 - 100%
  • Measurable or evaluable tumor parameter
  • No prior chemotherapy for NSCLC
  • Sufficient hematological parameter before start of therapy (leucocytes > 3.500/µl and platelets > 100.000/µl).
  • Sufficient liver function (bilirubin < 1,6mg/dl)
  • Sufficient renal function (creatinine < 1,5mg/dl and clearance > 60ml/min)
  • Minimal estimated life expectancy > 3 months
  • Written informed consent for study attendance
  • Patient accessibility for therapy and follow up
  • No attendance to an other study

Exclusion criteria

  • Small-cell lung cancer oder tumors with small-cell fractions
  • Local advanced irradiable stage III
  • Previous chemotherapy because of other diseases, not longer than 3 years ago
  • Simultaneous radiation of all present tumor manifestations
  • Simultaneous or not longer than 3 years ago secondary malignancy, except carcinoma in situ of the cervix or dermal cancer, others than melanoma
  • Respiratory insufficiency
  • Heart insufficiency NYHA III and IV
  • Peripheral arteriosclerosis stage III and IV
  • Neurological and psychiatric diseases, which affect understanding of the study concept and the possibility to keep conditions of the protocol
  • Pregnancy, breastfeeding or not ensured contraception
  • HIV-infection
  • Active hepatitis B and C
  • Manifest infectious diseases before start of therapy
  • Minimal estimated life expectancy < 3 months
  • No written informed consent of the patient for study attendance and storage and disclosure of disease data according to the protocol

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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