Randomized Study on the Effects of Moderate Anaemia in Free Microvascular Tissue Transfer

University of Zurich (UZH)

Status: Withdrawn

Conditions: Open Fracture of Foot; Tumor

Study type: Observational

Funder types: Other

Identifiers

NCT01848431

FF-HTC Verson 1-3

Details and patient eligibility

About

The evaluation of Perfusion of free flaps in patients with moderate anaemia and possible reduction of the transfusion threshold.

• Trial with surgical intervention

Full description

In study group 1 patients will be kept at a hematocrit level below 28% and only receive transfusions if symptomatic or the fall below 25%. Patients in group 2 will receive transfusions to reach a hematocrit always above 30%.

Tissue perfusion in free flaps will be measured with indocyanine green fluorescence angiography, confocal microscopy and oxygen partial pressure measurement probes.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• planned defect reconstruction with free flap and preoperative hematocrit of 28% or below

Exclusion criteria

• coagulation disorder
• Jehovah's witness
• iodine allergy
• renal or hepatic insufficiency

Trial design

0 participants in 2 patient groups

anaemia group

Description:

no blood transfusions will be given until hct falls under 25%

normal hct group

Description:

patients in group 2 will receive transfusions as is currently standard protocol outside the study