Randomized Trial of Mobilized Blood/Marrow Versus Blood Transplant

Peking University

Status: Withdrawn

Conditions: Leukemia

Treatments: Procedure: transplant with PBSCs

Study type: Interventional

Funder types: Other

Identifiers

NCT01617473

PUPH IRB [2012] (27)

Details and patient eligibility

About

The use of peripheral blood stem cells(PBSCs) is rapidly growing in the allogeneic transplantation setting as an alternative to bone marrow (BM).It was found that the use of PBSCs is associated with faster hematologic recovery but have yielded differing results regarding the incidence of graft-versus-host-disease (GVHD) and relapse.

The study hypothesis:

transplantation of mobilized PBSC to haploidentical donor with standard-risk leukemia had comparable engraftment and non-relapse mortality to mobilized BM combined with PBSCs

Full description

The donors were primed with granulocyte-colony stimulating factor (G-CSF) injected subcutaneously for five consecutive days. In the trial group, the PBSCs were harvested on the fourth and fifth day;in the control group, the bone marrow cells were harvested on the fourth day and the PBSCs were harvested on the fifth day.

Sex: All

Ages: 2 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Standard risk of Recipients of haploidentical stem cell transplantation with myeloablative conditioning regimens

Exclusion criteria

• Active, uncontrolled infection

Trial design

0 participants in 2 patient groups

procedure/surgery

Experimental group

Description:

transplant with G-CSF mobilized PBSCs

Treatment:

Procedure: transplant with PBSCs

other

No Intervention group

Description:

no intervention after transplant with mobilized BMPB