Ranibizumab Therapy for Choroidal Neovascularization (CNV) Asociated With Angioid Streaks

University of Illinois

Status and phase

Withdrawn

Phase 2

Phase 1

Conditions

Angioid Streaks

Treatments

Drug: ranibizumab

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT01015495

fvf 3763s

Details and patient eligibility

About

The purpose of this study is to determine whether injections of ranibizumab into the eye are safe and well tolerated when given to subjects in multiple doses.

Full description

Choroidal neovascularization is a hallmark of angioid streaks, and presumably VEGF-driven. Ranibizumab has been shown to be effective in CNV secondary to age-related macular degeneration. Therefore, we hypothesize that ranibizumab may be efficacious in the treatment of CNV secondary to angioid streaks

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Ability to provide written informed consent and comply with study assessments for the full duration of the study
Age > 18 years
Angioid streaks
Subfoveal CNV of recent onset with the following characteristics
Absence of subfoveal fibrosis
Fibrosis less than 25% of the lesion
Presence of blood, subretinal fluid, and/or lipid
New onset symptoms within 12 weeks
Visual acuity 20/40 to 20/800 on an ETDRS chart

Exclusion criteria

Prior treatment of subfoveal CNV in the study eye
Age-related macular degeneration
Uncontrolled glaucoma
High myopia (> -10.00 D spherical equivalent)
Prior retinal detachment
Media opacity preventing adequate view of the retina
Planned cataract surgery in the next 3 months
Current chemotherapy for cancer
Immunocompromised state
Pregnancy (positive pregnancy test) or lactation
Premenopausal women not using adequate contraception.
Any other condition that the investigator believes would pose a significant hazard to the subject if the investigational therapy were initiated
Participation in another simultaneous medical investigation or trial
History of any previous treatment for angioid streaks