Rapid Analysis of Infections by Spectrometry of Exhaled Breath (RAISE)

Universitaire Ziekenhuizen KU Leuven

Status: Enrolling

Conditions: Respiratory Tract Infections; Hematologic Diseases

Treatments: Diagnostic Test: Breath analysis

Study type: Observational

Funder types: Other

Identifiers

NCT03299608

S60785

Details and patient eligibility

About

To quantify the diagnostic, prognostic and therapeutic value of spectrometric analysis of exhaled breath from hematological patients with respiratory infection.

Enrollment: 246 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18y at start of study

• One of the following diagnoses:

  • De novo, refractory or relapsed AML/MDS receiving intensive chemotherapy
  • De novo, refractory or relapsed ALL/T-lymphoblastic lymphoma receiving intensive chemotherapy
  • Aplastic anemia requiring ATG therapy
  • Any patient admitted for either autologous hematopoietic stem cell transplantation. Transplantation may not have been performed at time of enrolment.
  • Any patient admitted with allogeneic hematopoietic stem cell transplantation within the last year, or planned during this admission.

• Written informed consent obtained from the patient

Exclusion criteria

• Hematological disease beyond the specified inclusion criteria
• Signs of active respiratory infection
• If previously enrolled: incomplete clearance of all signs of respiratory infection (both clinically, microbiologically and radiologically).