Rapid Assessment of Donor Liver Quality

Shanghai Jiao Tong University

Status: Unknown

Conditions: Transplant; Failure, Liver

Treatments: Diagnostic Test: LSCM examination

Study type: Observational

Funder types: Other

Identifiers

NCT03647059

SHLTQC-2

Details and patient eligibility

About

Aims：

1. Conduct multi-center, prospective and open research on liver quality assessment and establish LSCM liver quality assessment system
2. Classification of liver quality grades by LSCM for different pathological conditions (steatosis, fibrosis, hepatocyte necrosis, etc.)
3. Compare the specificity and sensitivity of LSCM evaluation results with the results of liver donor quality evaluation and intraoperative pathological biopsy results.
4. LSCM classifies the quality of donor liver and compares the recovery of liver function on the first day after liver transplantation.
5. LSCM grades the quality of donor liver and compares the long-term prognosis

Enrollment: 300 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All donor livers to be used for liver transplantations

Exclusion criteria

• Exclusion of multiple organ transplantation
• Exclusion of detached transplantation and partial liver transplantation, etc.
• Removal of blood type incompatible patients for transplantation
• Exclusion of poor donor liver quality due to surgical technique (such as hepatic artery embolization) , portal vein thrombosis, etc.)
• Any form of substance abuse, mental illness or any disease that the investigator believes may interfere with the patient's understanding of the research requirements.
• Can not complete routine research follow-up, and other circumstances that the investigator believes are not suitable for the experiment.

Trial design

300 participants in 1 patient group

LSCM examination

Treatment:

Diagnostic Test: LSCM examination