Rapid DFLC Response Predict CHR in AL Amyloidosis

Peking University

Status: Enrolling

Conditions: Systemic AL Amyloidosis

Treatments: Drug: Dexamethasone; Drug: Dara SC; Drug: Dara IV; Drug: Cyclophosphamide (CTX); Drug: Bortezomib (drug)

Study type: Observational

Funder types: Other

Identifiers

NCT06627309

2023PHB319-001-02

Details and patient eligibility

About

Light chain amyloidosis (AL amyloidosis) is a rare plasma cell dyscrasia characterized by the deposition of insoluble amyloid fibrils in multiple organ systems. The treatment of amyloidosis primarily relies on anti-plasma cell therapy and supportive care. The application of anti-plasma cell therapy has significantly improved outcomes in patients with AL amyloidosis. Standard first-line therapy typically includes daratumumab, bortezomib, cyclophosphamide, and dexamethasone (Dara-BCD), achieving a complete hematologic response in nearly 60% of patients.The depth and speed of the hematologic response are strongly correlated with organ response and overall survival. An early achievement of a complete hematologic response is particularly crucial in cases of AL amyloidosis characterized by significant organ involvement. The median time to a hematologic response for the daratumumab based treatment is only 7-9 days. The retrospective data showed that the hematologic response in Day 7 in Cycle 1 (C1D7) may predict the complete hematologic response rate. In order to validate the conclusion, the investigator design this prospective study.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Diagnosis of systemic AL amyloidosis;
2. Daratumumab, bortezomib, dexamethasone used in treatment;
3. Informed consent explained to, understood by and signed by the patient;
4. dFLC ≥ 50 mg/L;

Exclusion criteria

1. Fulfill with the criteria of active multiple myeloma or active lymphoplasmacytic lymphoma;
2. Presence of other tumors which is/are in advanced malignant stage and has/have systemic metastasis;
3. Severe or persistent infection that cannot be effectively controlled;
4. Presence of severe autoimmune diseases or immunodeficiency disease;
5. Patients with active hepatitis B or hepatitis C ([HBVDNA+] or [HCVRNA+]); Patients with HIV infection or syphilis infection;
6. Any situations that the researchers believe will increase the risks for the subject or affect the results of the study.

Trial design

50 participants in 1 patient group

Group 1

Description:

All patients in this cohort receive daratumumab, bortezomib and dexamethasone as treatment. All patients receive additional sFLC examination in C1D7, C1D14.

Treatment:

Drug: Bortezomib (drug)

Drug: Cyclophosphamide (CTX)

Drug: Dara IV

Drug: Dara SC

Drug: Dexamethasone