Rapid Diagnosis of Severe Respiratory Tract Infectious Diseases and Screening of Biomarkers for Stratified Diagnosis

Chinese PLA General Hospital (301 Hospital)

Status: Not yet enrolling

Conditions: Biomarkers; Severe Pneumonia

Study type: Observational

Funder types: Other

Identifiers

NCT06533514

Pneumonia and Biomarkers

Details and patient eligibility

About

The purpose of this study is to clarify the biomarkers for rapid diagnosis and stratified diagnosis of severe respiratory tract infectious diseases through clinical experiments.

Full description

Methods: The relationship between relevant biomarkers and stratified diagnosis was analyzed by collecting laboratory and etiological examinations of patients with severe pneumonia.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Meets the diagnostic criteria for severe pneumonia；
• Age≥18 years old and < 80 years old；
• Willing to sign informed consent for the course of the study；

Exclusion criteria

• Patients with intracranial hypertension, acute coronary syndrome, pleural fistula, pneumothorax, or subcutaneous emphysema;
• Pregnant and lactating patients;
• Severely hemodynamically unstable (an increase in vasopressors by more than 30% in the first 6 hours, or norepinephrine >0.5mg/kg/min);
• Those who do not consent to participate in this study；

Trial design

100 participants in 3 patient groups

mild

Description:

According to the APACHE II score, SOFA score and PSI score, the enrolled patients were divided into three groups: mild, moderate and severe.

moderate

Description:

According to the APACHE II score, SOFA score and PSI score, the enrolled patients were divided into three groups: mild, moderate and severe.

severe

Description:

According to the APACHE II score, SOFA score and PSI score, the enrolled patients were divided into three groups: mild, moderate and severe.