Rapid Diagnostic Tests for Assessment of Initial Clearance and Detection of Recurrent Malaria Infections

Anders Björkman

Status: Completed

Conditions: Plasmodium Falciparum Malaria

Treatments: Device: HRP2 and LDH based rapid diagnostic tests for P.falciparum

Study type: Observational

Funder types: Other

Identifiers

NCT01843764

KI-MUHAS1 (Registry Identifier)

RDT-ClearTZ1

Details and patient eligibility

About

The aim of the study was to follow clearance of malaria infections and detection of new malaria episodes after initiation of antimalarial treatment in Tanzanian children. For this purpose the investigators used five diagnostic tools, 2 Rapid Diagnostic tests based on Histidine Rich Protein 2(HRP2) and Lactate dehydrogenase(LDH), 2 microscopical methods and one polymerase chain reaction (PCR). The investigators followed the 53 enrolled children during 42 days.

Enrollment: 53 patients

Sex: All

Ages: 6 to 59 months old

Volunteers: No Healthy Volunteers

Inclusion criteria

• children between 6-59 months
• fever (≤37.5 C) or history of fever during the preceding 24 hours
• confirmed P.falciparum monoinfection
• uncomplicated malaria
• parasite density between 2000-250.000/µL
• willing/able to comply with the 42 day follow up
• informed concent from patient/guardian

Exclusion criteria

• children with history of antimalaria drug intake within the last two weeks
• symptoms / signs of severe disease

Trial design

53 participants in 1 patient group

children with malaria

Description:

Tanzanian children between 6-59 months with an uncomplicated P.falciparum monoinfection, followed after arthemeter-lumefantrine treatment according to national treatment guidelines

Treatment:

Device: HRP2 and LDH based rapid diagnostic tests for P.falciparum