Rapid Maxillary Expansion Related Oxidative Stress and Periodontal Results

Recep Tayyip Erdogan University Training and Research Hospital

Status: Completed

Conditions: Maxillary Expansion

Treatments: Other: Periodontal measurements (plaque index, gingival index and probing pocket depth scores ); Procedure: Rapid maxillary expansion with Hyrax appliance; Other: Biochemical Sample Supply (Collection of serum and saliva samples)

Study type: Interventional

Funder types: Other

Identifiers

NCT06937775

BAP 2015/306

Details and patient eligibility

About

The aim of this study was to investigate the effects of rapid maxillary expansion on local and systemic oxidative stress levels. Thirty-five volunteer patients (17 females and 18 males) who needed rapid maxillary expansion will be included in the study. Serum and saliva samples will be collected from each patient during four different periods: a week before the treatment (T0), on the day of sutural separation (T1), at the end of the active expansion period (T2), and after the completion of a 3-month retention period (T3). To evaluate the patients' periodontal status, plaque index, gingival index, and probing pocket depth scores will be recorded for each period. 8-hydroxydeoxyguanosine (8-OHdG), total oxidative status (TOS), total antioxidant capacity (TAS), and oxidative stress index (OSI) biomarkers will be evaluated to determine the local and systemic oxidative stress levels.

Enrollment: 35 patients

Sex: All

Ages: 11 to 16 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Being between 11-15 years of age,
• Having an indication for maxillary expansion due to maxillary stenosis,
• Being highly cooperative, performing adequate oral care,
• Being periodontally healthy,
• Not having cleft lip and/or palate anomalies,
• Not having any systemic disease,
• Not having used any medication including antibiotics and anti-inflammatory drugs in the last 6 months,
• Not being substance addicted and not smoking.

Exclusion criteria

• Having inadequate oral hygiene
• Being periodontally unhealthy
• Having cleft lip and/or palate anomalies,
• Having any systemic disease,
• Having used any medication including antibiotics and anti-inflammatory drugs in the last 6 months,
• Being substance addicted and not smoking.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Double Blind

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35 participants in 4 patient groups

TO

Other group

Description:

1 week before the placement of the Hyrax appliance

Treatment:

Other: Biochemical Sample Supply (Collection of serum and saliva samples)

Other: Periodontal measurements (plaque index, gingival index and probing pocket depth scores )

T1

Other group

Description:

The day of the first clinical observation of sutural opening (5-7 days after activation)

Treatment:

Other: Biochemical Sample Supply (Collection of serum and saliva samples)

Procedure: Rapid maxillary expansion with Hyrax appliance

Other: Periodontal measurements (plaque index, gingival index and probing pocket depth scores )

T2

Other group

Description:

The day of completion of active expansion (3-4 weeks)

Treatment:

Other: Biochemical Sample Supply (Collection of serum and saliva samples)

Procedure: Rapid maxillary expansion with Hyrax appliance

Other: Periodontal measurements (plaque index, gingival index and probing pocket depth scores )

T3

Other group

Description:

The day of completion of the 3-month reinforcement period

Treatment:

Other: Biochemical Sample Supply (Collection of serum and saliva samples)

Procedure: Rapid maxillary expansion with Hyrax appliance

Other: Periodontal measurements (plaque index, gingival index and probing pocket depth scores )