Rapid Non-Invasive Brain Stimulation for OCD (oTMS)

Stanford University

Status: Completed

Conditions: OCD

Treatments: Device: MagPro X100 by MagVenture

Study type: Interventional

Funder types: Other

Identifiers

NCT03404609

43421

Details and patient eligibility

About

The purpose of this study is to understand how cortical stimulation affects Obsessive-Compulsive Disorder (OCD) symptoms.

Full description

Obsessive-Compulsive Disorder (OCD) is a chronic and disabling disorder that costs the economy over $2 billion annually and represents a significant public health problem. This study aims to understand how cortical stimulation affects Obsessive-Compulsive Disorder

Enrollment: 7 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18-80
• Primary diagnosis of OCD
• Sufficient severity of OCD symptoms
• Capacity to provide informed consent

Exclusion criteria

• Psychiatric or medical conditions or medications that make participation unsafe
• Pregnant or nursing females
• Previous exposure to TMS or ECT
• History of any implanted device or psychosurgery
• Presence of metallic device or dental braces

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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7 participants in 1 patient group

Accelerated course of modified continuous theta-burst stimulation (cTBSmod)

Experimental group

Description:

Participants received 5 consecutive days of accelerated cTBSmod to the right frontal pole. Each cTBSmod session was comprised of 1800 pulses, delivered in a continuous train of 600 bursts. Each burst contained 3 pulses at 30 Hz, repeated at 6 Hz. Ten sessions were applied per day (18,000 pulses/day, hourly) (90,000 total pulses) using a Magventure Magpro X100. Stimulation was delivered at 90% resting motor threshold (depth corrected). Localite Neuronavigation System was used to position the TMS coil over the individualized stimulation target.

Treatment:

Device: MagPro X100 by MagVenture