Rapid Pancreatic and Ovarian Screening MR Imaging With Motion Corrected T1, T2, and Advanced Diffusion Weighted Imaging for Patients With BRCA Mutation Who Undergo Screening Breast MRI

Memorial Sloan Kettering Cancer Center (MSK)

Status: Active, not recruiting

Conditions: Screening Breast MRI in Patients Who Are BRCA Mutation Carriers

Treatments: Behavioral: Optional Screening Questionnaire; Device: MRI

Study type: Observational

Funder types: Other

Identifiers

NCT02462460

15-120

Details and patient eligibility

About

The purpose of this study is to create a rapid scan of the pancreas and ovaries that could be used in the future to screen patients at risk for pancreatic or ovarian cancers. Currently, Magnetic Resonance Imaging (MRI) examinations of the pancreas and ovaries can last 30-45 minutes each. The investigators hope to create a rapid pancreatic and ovarian MRI evaluation that can be used as a screening tool that is completed in approximately 15 minutes. They will compare different tools available on modern MRI scanners to see which one reliably offers high quality images of the pancreas and ovaries.

Enrollment: 63 patients

Sex: Female

Ages: 30+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

A minimum of 5 and maximum of 60 evaluable patients will be imaged on this study. Description of the subject inclusion and exclusion criteria are listed below.

Inclusion Criteria:

• BRCA 1 or 2 mutation
• Age ≥ 30
• Patients scheduled to undergo screening breast MRI with contrast

Exclusion Criteria:

• Patients with known breast cancer
• Patients unable to complete their scheduled breast MRI
• Patients with prior pancreatic surgery or cancers
• Patients with prior ovarian cancer or surgery involving removal of one or both ovaries
• Patients with prior abdominal or pelvic surgery

Trial design

63 participants in 1 patient group

Patients with BRCA mutation

Description:

The purpose of this study is to optimize rapid pancreatic and ovarian MR screening protocols using T1, T2 and DW imaging sequences in BRCA mutation carriers. Each screening MR protocol is considered optimized if we reach 5 consecutive patients with technically adequate image quality. We will enroll up to 60 patients to perform the MR screening protocol, if the initial MR sequence parameters do not yield technically adequate MR images in a single patient, we will stop and modify our imaging protocol. We will continue to modify the technique until we reach 5 consecutive patients with technically adequate MR images for both on all imaging sequences. Thus, it is possible we will optimize different imaging sequences at different time points in our study. We plan to enroll at least 5 patients, and up to 60 patients with BRCA mutation who undergo breast MRI for this study. Participants will receive a copy of the questionnaire on the day of their Breast MRI.

Treatment:

Behavioral: Optional Screening Questionnaire

Device: MRI