Rapid Prehospital ACcess to ECPR in Prague (RACE)

General University Hospital, Prague

Status: Enrolling

Conditions: Extracorporeal Cardiopulmonary Resuscitation; Out of Hospital Cardiac Arrest

Treatments: Other: Extracorporeal cardiopulmonary resuscitation (ECPR)

Study type: Interventional

Funder types: Other

Identifiers

NCT06789978

134/23 S-IV

Details and patient eligibility

About

A prospective pilot feasibility study of prehospital ECPR in patients with refractory OHCA

Full description

The aim of this pilot prospective study is to assess the feasibility and effectiveness of a prehospital extracorporeal cardiopulmonary resuscitation (ECPR) system for refractory out-of-hospital cardiac arrest (OHCA) in Prague, compared to a historical cohort of in-hospital ECPR recipients from the Prague OHCA trial.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Estimated age 18-70 years
• Refractory out-of-hospital cardiac arrest (3 unsuccessful defibrillations and/or at least 10 minutes of resuscitation in case of pulseless electrical activity)
• Witnessed cardiac arrest
• ECPR team available
• ECPR team alert within 20 minutes from the emergency call

Exclusion criteria

• Unwitnessed cardiac arrest
• Asystole
• ETCO2 less than 10 mmHg upon ECPR team arrival
• Known limitations of intensive care (Do Not Resuscitate - DNR status)
• Known severe neurological impairment prior to cardiac arrest (mRS 4-6)
• Suspected or known pregnancy

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Prehospital extracorporeal cardiopulmonary resuscitation (ECPR)

Experimental group

Description:

Prehospital ECPR will include all patients who enter the study and receive ECPR. The historical control group will consist of patients from the Prague OHCA study who received in-hospital ECPR and fulfilled all relevant inclusion and exclusion criteria for this study.

Treatment:

Other: Extracorporeal cardiopulmonary resuscitation (ECPR)