Rate Control in Atrial Fibrillation

Creighton University

Status and phase: Unknown; Phase 4

Conditions: Atrial Fibrillation

Treatments: Drug: Carvedilol; Drug: Metoprolol tartrate

Study type: Interventional

Funder types: Other

Identifiers

NCT02251509

624918

Details and patient eligibility

About

This study will evaluate the efficacy of metoprolol tartrate compared to carvedilol on heart rate control in patients with atrial fibrillation and a rapid ventricular rate.

Enrollment: 20 estimated patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Permanent atrial fibrillation
• Baseline ventricular rate (prior to treatment) > 110 bpm

Exclusion criteria

• History of accessory tract re-entry tachycardia
• Ejection fraction < 35% or history of NYHA Class III/IV stage C/D heart failure
• Acute coronary syndrome, percutaneous coronary intervention, or cardiac surgery in the past 2 months
• Child-Pugh class B or C hepatic dysfunction
• Uncontrolled hypertension
• Thyroid disease
• Intolerance to beta-blockers
• History of lung disease resulting in hospitalization in the past year

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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20 participants in 2 patient groups

Carvedilol

Experimental group

Description:

carvedilol BID for 2 weeks

Treatment:

Drug: Carvedilol

Metoprolol tartrate

Experimental group

Description:

Metoprolol tartrate BID for 2 weeks

Treatment:

Drug: Metoprolol tartrate