Rate of Duodenal-biliary Reflux Increases in Patients With Recurrent Common Bile Duct Stones

Air Force Military Medical University of People's Liberation Army

Status: Completed

Conditions: Common Bile Duct Gall Stones; Common Bile Duct GallStones

Treatments: Other: standard barium meal examination

Study type: Observational

Funder types: Other

Identifiers

NCT02329977

20130508-2

Details and patient eligibility

About

ERCP is the primary choice for removal of common bile duct stone (CBDS) currently. However, 4-24% patients underwent recurrence after successful clearance of CBDS. Stone re-formation due to chronic inflammation of biliary duct is generally considered an important cause of CBDS recurrence, which is associated with duodenal-biliary reflux (DBR) after sphincterotomy. Although it was believed that DBR was the important cause of CBDS recurrence, the direct evidence was still lacking. Here we conducted a case control study to investigate the DBR rate in patients with recurrent CBDS after ERCP.

Enrollment: 64 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with common bile duct stone underwent successful stone removal by ERCP in Xijing Hospital of Digestive Diseases.

Exclusion criteria

• Gallbladder stones or hepatolithiasis;
• Stenosis of biliary duct;
• Incomplete common bile duct stone removal by ERCP;
• Common bile duct stent;
• Unable to provide informed consent.

Trial design

64 participants in 2 patient groups

Recurrent group

Description:

Patients with history of recurrent common bile duct stone after successfully ERCP stone remove.

Treatment:

Other: standard barium meal examination

Control group

Description:

Patients without history of recurrent common bile duct stone after successfully ERCP stone remove.

Treatment:

Other: standard barium meal examination