Rates DMBT1 ( Glycoprotein) in Sputum of CF Patients With Pseudomonas Aeruginosa

University Hospital, Lille

Status: Terminated

Conditions: Malignant Brain Tumor

Study type: Observational

Funder types: Other

Identifiers

NCT02880111

2012_44

2014-A00259-38 (Other Identifier)

PHRCI-2012 (Other Identifier)

Details and patient eligibility

About

Rates of DMBT1 (Glycoprotein like) in Sputum of CF Patients with or without may be different according to their Pseudomonas Aeruginosa chronic colonization status. The aim of this study is to compare rates of DMBT1 (Glycoprotein like) in Sputum of CF patients with or without a Pseudomonas Aeruginosa chronic colonization.

Full description

Rates of DMBT1 (Deleted in Malignant Brain Tumor 1) will be compared between 2 groups of 30 CF patients : group 1 : with Pseudomonas Aeruginosa chronic colonization and group 2 30 CF patients without Pseudomonas Aeruginosa chronic colonization.

Enrollment: 1 patient

Sex: All

Ages: 6+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• CF patient 6 years
• Availability of sputum
• Signed Informed consent

Exclusion criteria

• Cardiac insufficiency
• Anti-inflammatory drugs on going
• Oral corticosteroid therapy
• Inhaled corticosteroids during the two weeks before inclusion,
• Patient awaiting lung transplantation
• Patient with a past history of heart/lung transplantation
• Patient with a sputum examination positive for : atypical mycobacteria, Burkholderia cepacia, Stenotrophomonas maltophilia,
• Patient chronically colonized with multiresistant Pseudomonas aeruginosa
• Orkambi© or Kalydeco© therapy
• Change of the CF treatment during the last 4 weeks +/- 2 days before inclusion : corticosteroid, pancreatic extracts, antisecretory drugs...

Trial design

1 participants in 2 patient groups

group 1

Description:

CF patients with Pseudomonas aeruginosa chronic colonization.

group 2

Description:

CF patients without a Pseudomonas aeruginosa chronic colonization.