RCT Versus Placebo of rTMSQP Over Visual Cortex for the Prevention of Chronic Migraine

University of Liege

Status: Withdrawn

Conditions: Chronic Migraine

Treatments: Device: Super Rapid Magstim Stimulator; Device: Super Rapid Magstim Stimulator (sham)

Study type: Interventional

Funder types: Other

Identifiers

NCT02122744

CB-1331

Details and patient eligibility

About

Evaluation of inhibiting rTMS QP over the visual cortex for the prevention of chronic migraine. The aim of the study is to confirm that inhibiting rTMS QP is capable to decrease the frequency of migraine and if its effect is stronger than placebo effect.

Full description

The investigators have already inquired if inhibiting rTMS QP over the visual cortex determines a reduction of frequency of migraine in a previous study. After 2 weekly sessions for a month, the investigators demonstrated a reduction of 47% in migraine frequency. In this study, the investigators aim to compare rTMS QP effect with the placebo effect and to evaluate if rTMS QP is capable to induce changes in VEP, CHEPS and QST.

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosis of chronic migraine (ICHD III beta 1.3) with or without medication overuse.

Exclusion criteria

• other diseases or contraindication for the magnetic stimulation (epilepsy, pacemaker, metallic prothesis)

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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0 participants in 2 patient groups, including a placebo group

Super Rapid Magstim Stimulator rTMS QP

Active Comparator group

Description:

rTMS QP is delivered over the visual cortex for 30 minutes, 2 times a week for 8 weeks, in 15 patients

Treatment:

Device: Super Rapid Magstim Stimulator

Placebo

Placebo Comparator group

Description:

rTMS QP placebo (coil perpendicular to the scalp) is delivered over the visual cortex for 30 minutes, 2 times a week for 8 weeks, in 15 patients.

Treatment:

Device: Super Rapid Magstim Stimulator (sham)