Re-Evaluation of the Effects of High PEEP During General Anesthesia For Surgery (REPEAT)

Hospital Israelita Albert Einstein

Status: Completed

Conditions: Mechanical Ventilation Complication; Surgery; Pulmonary Complication

Treatments: Behavioral: High PEEP; Behavioral: Low PEEP

Study type: Observational

Funder types: Other

Identifiers

NCT03937375

REPEAT (Other Identifier)

Details and patient eligibility

About

Aiming to understand the isolated impact of high PEEP in patients undergoing mechanical ventilation for general anesthesia for surgery, three appropriately sized international multicentre randomized controlled trials have been performed over recent years: the 'PROtective Ventilation using HIgh versus LOw PEEP trial (PROVHILO), the 'individualized PeRioperative Open-lung Ventilation trial' (iPROVE), and the 'Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients trial' (PROBESE). These three trials had several similarities in key areas of their study protocols, inclusion and exclusion criteria, and collected data, and even the primary and secondary outcomes. Of note, the three trials combined high PEEP with recruitment manoeuvres. This allows an individual patient data meta-analysis.

Enrollment: 3,837 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Enrolled into one of the three studies (PROVHILO, iPROVE or PROBESE) to either high PEEP or low PEEP

Trial design

3,837 participants in 2 patient groups

High PEEP

Description:

Use of high levels of PEEP with recruitment maneuvers

Treatment:

Behavioral: High PEEP

Low PEEP

Description:

Use of low levels of PEEP without recruitment maneuvers

Treatment:

Behavioral: Low PEEP