Real-time Monitoring of Motor Cortical Activity Induced by Low-frequency Repetitive Transcranial Magnetic Stimulation

Samsung Medical Center

Status: Completed

Conditions: Healthy

Treatments: Device: low frequency rTMS + Navigation System; Device: Sham low frequency rTMS + Navigation System; Device: only low frequency rTMS

Study type: Interventional

Funder types: Other

Identifiers

NCT04019028

2014-05-021

Details and patient eligibility

About

In this study, we investigated the effect of low-frequency repetitive trans cranial magnetic stimulation, one of the noninvasive brain stimuli, on the functional changes of the bilateral motor cortical activity in normal subjects using functional near infrared spectroscopy (fNIRS).

Full description

In normal subjects,

1. the effect of low-frequency repetitive transcranial magnetic stimulation on cerebral cortex are measured in real time using fNIRS.
2. Changes in cerebral cortical activity before and after stimulation are measured using the motor function test and the motor-induced potential test

Enrollment: 10 patients

Sex: All

Ages: 19 to 69 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy adult men and women without history of central nervous system disease and abnormalities

Exclusion criteria

• Under 18 years old, 70 years old or older
• A person who has inserted a metal object in a skull
• A person with complete occlusion of the carotid artery
• A person with epilepsy
• Pregnant and lactating women
• Who is not eligible for the test

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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10 participants in 3 patient groups

Navigated low frequency rTMS

Experimental group

Description:

Application of 1Hz low frequency repetitive transcranial magnetic stimulation to the primary motor area of the dominant hemisphere using a navigation system. Using the BrainSight instrument, a navigation system, the TMS coil position can be fixed on the point precise target area based on the subject's MRI image.

Treatment:

Device: low frequency rTMS + Navigation System

only low frequency rTMS(not using Navigation System)

Experimental group

Description:

Application of low frequency repetitive transcranial magnetic stimulation to the primary motor area of the dominant hemisphere not using a navigation system. TMS coil is fixed on the target area based on MEP hotspot.

Treatment:

Device: only low frequency rTMS

Navigated Sham rTMS

Sham Comparator group

Description:

Application of repetitive transcranial magnetic stimulation with sham mode(no stimulation) to the primary motor area of the dominant hemisphere using a navigation system. Using the BrainSight instrument, a navigation system, the TMS coil position can be fixed on the point precise target area based on the subject's MRI image. Sham stimulation is stimulated by the same frequency, intensity and time as the actual stimulus in such a way that the 8-shaped coil is placed at a 90 degree angle to the scalp in the same manner as rTMS and sounds are heard but the magnetic stimulus is not transmitted to the cerebrum

Treatment:

Device: Sham low frequency rTMS + Navigation System