Real-World Cohort Study of Cardiopulmonary Function in Chinese Patients With Cardiovascular Disease: CPET Evaluation and Five-Year Prognostic Follow-Up Based on a Multicenter Structured Data Platform (China-CPET)

Guangdong Provincial People's Hospital (Guangdong Provincial Academy of Medical Sciences)

Status: Invitation-only

Conditions: Cardiac Death; Unplanned Repeat Revascularization; Stroke; Non-fatal Myocardial Infarction; MACE; Cardiac Rehospitalization

Study type: Observational

Funder types: Other

Identifiers

NCT07130968

KY2025-499-03

Details and patient eligibility

About

The goal of this observational study is to observe the characteristics of cardiopulmonary exercise testing (CPET) parameters in patients across different cardiovascular diseases and to evaluate the predictive value of multiparameter cardiopulmonary indices for 5-year major adverse cardiovascular events (MACE).

Full description

To investigate the CPET characteristics in patients with various cardiovascular diseases (including acute myocardial infarction, heart failure, cardiomyopathy, valvular heart disease, coronary artery disease, and perioperative cardiac surgery), with annual follow-up of major adverse cardiovascular events (MACE) for five years, and to establish the predictive value of combined CPET parameters for MACE in this population

Enrollment: 200,000 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Age: 18-80 years,
2. Ability to comprehend and provide written informed consent.

Exclusion criteria

1. Comorbid severe conditions (e.g., recent acute myocardial infarction, unstable angina, uncontrolled arrhythmias, severe aortic coarctation or descending aortic aneurysm, acute myocarditis or pericarditis, acute congestive heart failure, acute respiratory failure, resting oxygen saturation <93%, recent arterial or pulmonary embolism, pulmonary edema).
2. Conditions potentially exacerbated by exercise (e.g., acute cardiac insufficiency, exercise-induced asthma, epilepsy).
3. Physical disability due to musculoskeletal or neuromuscular disorders.
4. Pregnancy or lactation.
5. Patients deemed unsuitable for participation by the investigator.

Trial design

200,000 participants in 2 patient groups

cardiovascular disease patient with MACE

Description:

cardiovascular disease patient with MACE（Cardiac death, unplanned revascularization, cardiac readmission, non-fatal myocardial infarction, and stroke）

cardiovascular disease patient without MACE