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Real-world Evaluation of BEOVU (Brolucizumab) Effectiveness and Durability for Treatment of Neovascular (Wet) Age-related Macular Degeneration (AMD)

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Novartis

Status

Completed

Conditions

Neovascular (Wet) Age-related Macular Degeneration

Study type

Observational

Funder types

Industry

Identifiers

NCT06184360
CRTH258A2014

Details and patient eligibility

About

This was a retrospective, observational cohort study. Data were analyzed from the Intelligent Research in Sight (IRIS) registry from October 8, 2019, through November 26, 2021, with a follow-up period of 12 months following the first brolucizumab injection (index date).

Enrollment

2,079 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • At least 18 years old at the time of their first (index) injection of brolucizumab.
  • Had documented neovascular age-related macular degeneration (nAMD) on or within 3 years before the index injection.
  • Used only brolucizumab for at least 12 months (± 45 days) after the index injection, with at least 1 brolucizumab injection given within the first 6 months after the index injection and at least 1 additional brolucizumab injection given at 6-12 months after the index injection.

Exclusion criteria

  • Had received any other anti-VEGF agent between the index injection and 12-month follow-up.
  • Lacked information about the laterality of disease at the time of the index injection.
  • Lacked visual acuity assessments on or within 30 days before the index injection or at 6, 9, and 12 months after the index injection (all of the latter ± 45 days).

Trial design

2,079 participants in 2 patient groups

Treatment-Experienced
Treatment-Naive

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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