Real-world Evaluation of Prevalence of Ocular Adverse Events in Patients With Neovascular (Wet) Agerelated Macular Degeneration (AMD) Who Received Anti-VEGF Agents (IRIS Registry)
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About
In this cross-sectional study of patients with wet AMD who received ≥1 anti-VEGF injection (excluding brolucizumab), evidence was generated to describe the period prevalence of specific ocular AEs. The study was conducted using the IRIS Registry, and all results were based on the study period from 01/01/2019 to 12/31/2019.
Full description
This was a retrospective cohort study of eyes in adult patients with a diagnosis of wet AMD who were treated with anti-VEGF agents from 01/01/2019 to 12/31/2019.
IRIS Registry data from 01/01/2019 to 12/31/2019 for patients with a diagnosis of wet AMD who were treated with ≥1 anti-VEGF agent (excluding brolucizumab) were included.
- Identification period: Patients fulfilling the selection criteria during the period from 01/01/2019 to 12/31/2019 were identified
- Index date: 01/01/2019
- Study Period: 01/01/2019 to 12/31/2019
- Pre-index period: 01/01/2018 to 12/31/2018
- Post-index period: 01/01/2019 to 12/31/2019
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Inclusion criteria
- ≥1 International Classification of Diseases, Clinical Modification-9/10 CM (ICD- 9/10) code for wet AMD in 2019
- ≥1 Healthcare Common Procedure Coding System (HCPCS) code (J code) or National Drug Code (NDC) code for treatment with an anti-VEGF agent (excluding brolucizumab) in 2019
- ≥18 years old in 2019
- ≥2 wet AMD-related office visits in 2019
Exclusion criteria
- Patient eyes that received >1 type of anti-VEGF treatment on the same date
- Patient eyes that did not have laterality any time during 2018-2019
- Treatment with brolucizumab during 2019
Trial design
331,541 participants in 4 patient groups
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Data sourced from clinicaltrials.gov
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