Real-world Evidence of COVID-19 Vaccines Effectiveness

Ivan S Moiseev

Status: Terminated

Conditions: COVID-19 Pneumonia

Treatments: Biological: COVID-19 Vaccines

Study type: Observational

Funder types: Other

Identifiers

NCT04981405

CDRU-003

Details and patient eligibility

About

This is an observational case-control study to evaluate COVID-19 vaccine effectiveness against hospitalisation with COVID-19 related conditions in St. Petersburg, Russia. Two sets of cases and control will be retrospectively analyzed to compare vaccination proportions and other characteristics to infer vaccine effectiveness from odds ratios. The first set of cases will be extracted from the data on hospitalisation of patients with COVID-19 to First Pavlov State Medical University of Saint-Petersburg hospitals, and controls will be patients hospitalised with other conditions. The second set of cases and controls will be based on patients referred to Medical Institute named after Berezin Sergey for computed tomography. Cases will be patients with positive SARS-CoV-2 status computed tomography confirmed pneumonia or patients referred to hospitalisation, and control will be patients without pneumonia and not referred to hospitalisation.

Enrollment: 182 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients hospitalized to clinics of First Pavlov State Medical University of Saint-Petersburg
• Patients referred to Medical Institute named after Berezin Sergey for computed tomography
• Available vaccination status

Exclusion criteria

• Refusal to provide information for research purposes at the time of hospitalization or reference to computed tomography

Trial design

182 participants in 2 patient groups

Patients hospitalised to clinics of First Pavlov State Medical University of Saint - Petersburg

Description:

450 cases - patients hospitalised with COVID-19 450 control - patients hospitalised without COVID-19 in the same period (surgical, oncological, cardiological, ophthalmologic, gastroenterological departments)

Treatment:

Biological: COVID-19 Vaccines

Patients referred to Medical Institute named after Berezin Sergey for computed tomography

Description:

Cases - patients with pneumonia confirmed after computed tomography. Controls - patients without pneumonia after computed tomography.

Treatment:

Biological: COVID-19 Vaccines