Real-World Outcomes of US Talazoparib-Treated Patients With Locally Advanced or Metastatic Breast Cancer

Pfizer

Status: Completed

Conditions: Breast Cancer

Treatments: Drug: Talazoparib

Study type: Observational

Funder types: Industry

Identifiers

NCT04987931

C3441053

Details and patient eligibility

About

This study is a retrospective, multi-site, patient-level medical chart review of US adult patients with locally advanced or metastatic breast cancer (ABC) who initiated talazoparib on or after October 16, 2018 and were managed by participating providers from Cardinal Health's Oncology Provider Extended Network (OPEN).

This study will describe patient characteristics, treatment patterns, and clinical outcomes of talazoparib-treated patients in real-world practice setting in US.

The primary population for this study includes:

-HER2-negative ABC patients with germline BRCA1/2 (gBRCA1/2) mutations treated with talazoparib monotherapy initiated on or after October 16, 2018 and ≥18 years of age at initiation of talazoparib.

Enrollment: 84 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosed with HER2-negative ABC

• gBRCA1/2 mutation(s)

• Treatment with talazoparib monotherapy initiated on or after October 16, 2018

  -≥18 years of age at initiation of talazoparib

• A minimum of 6 months follow-up time after initiation of talazoparib unless the patient died within this follow-up period

Exclusion criteria

• Participation in any BC clinical trial after initiation of talazoparib
• Treatment with a PARP inhibitor as neoadjuvant/adjuvant therapy
• gBRCA1/2 or HER2 status unknown
• Diagnosis of any other malignancy, except carcinoma in situ or nonmelanoma skin cancer, within the 5 years prior to data collection

Trial design

84 participants in 1 patient group

Primary population: Talazoparib-treated patients with HER2- ABC with gBRCA1/2m

Description:

HER2-negative ABC patients with gBRCA1/2 mutations treated with talazoparib monotherapy initiated on or after October 16, 2018 and ≥18 years of age at initiation of talazoparib.

Treatment:

Drug: Talazoparib