Real-World Study of Helicobacter Pylori Eradication Success and Its Determinants

Run-hua Li

Status: Completed

Conditions: HELICOBACTER PYLORI INFECTIONS

Treatments: Other: No Study-Assigned Intervention

Study type: Observational

Funder types: Other

Identifiers

NCT07374822

NYSZYYEC2024K049R002

Details and patient eligibility

About

This study aims to evaluate the real-world effectiveness of different treatment regimens used to eradicate Helicobacter pylori (H. pylori) infection in routine clinical practice. H. pylori is a common bacterial infection that can lead to chronic gastritis, peptic ulcers, and gastric cancer. Treatment success varies widely in real-world settings due to factors such as antibiotic resistance, patient characteristics, and treatment adherence.

This retrospective observational study will review medical records of patients who underwent H. pylori testing and/or eradication treatment at Shenzhen Hospital of Southern Medical University between 2016 and 2023. No additional tests, visits, or interventions will be performed beyond standard clinical care. The study will collect information on demographics, comorbidities, treatment regimens, test results, and eradication outcomes.

The primary goal is to determine the real-world eradication success rate of commonly used treatment regimens. A secondary goal is to identify factors that may influence treatment effectiveness. Findings from this study may help clinicians choose more effective treatment strategies and improve patient outcomes in everyday clinical practice.

Enrollment: 3,000 patients

Sex: All

Ages: 14+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 14 years.
• Patients who underwent Helicobacter pylori (H. pylori) testing and/or eradication treatment at Shenzhen Hospital of Southern Medical University between 2016 and 2023.
• Diagnosis of H. pylori infection based on the Sixth National Consensus Report on the Management of Helicobacter pylori Infection (Non-Eradication Section) or clinically accepted testing methods.

Exclusion criteria

• Children younger than 14 years old.
• Pregnant or breastfeeding women.
• Patients deemed unsuitable for participation by the investigator based on clinical judgment.

Trial design

3,000 participants in 1 patient group

Patients With Helicobacter pylori Infection

Description:

Participants who underwent H. pylori testing and/or eradication treatment at Shenzhen Hospital of Southern Medical University between 2016 and 2023. This cohort includes patients receiving different eradication regimens as part of routine clinical care. No study-assigned interventions are provided.

Treatment:

Other: No Study-Assigned Intervention