Real-World Study on Chinese Medicine for Treating Chikungunya Fever

Guangzhou University of Traditional Chinese Medicine

Status: Enrolling

Conditions: Chikungunya Fever

Study type: Observational

Funder types: Other

Identifiers

NCT07120724

ZE2025-299-01

Details and patient eligibility

About

This study aims to evaluate the effectiveness and safety of Chinese Medicine-used alone or combined with Western medicine-in treating chikungunya fever, a mosquito-borne viral disease causing fever, rash, and severe joint pain. With recent outbreaks in China (including over 3,000 cases in Foshan, Guangdong) and no specific antiviral treatment available, Chinese medicine may offer a valuable therapeutic option based on its symptom-relief and syndrome-specific approach.

Enrollment: 600 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Meets the suspected or confirmed diagnostic criteria for chikungunya fever;
2. Symptom onset ≤3 days before enrollment;
3. Actual prescribed treatment aligns with the study's group assignment (TCM, Western medicine, or combined therapy)
4. Signed informed consent form

Exclusion criteria

1. Severe chikungunya fever;
2. Participation in another drug clinical trial within the past 3 months;
3. Any other condition deemed by the investigator as unsuitable for enrollment.

Trial design

600 participants in 3 patient groups

Chinese Medicine Group

Description:

Intervention: Patients receive only TCM treatments, which may include herbal formulas (e.g., decoctions, granules) or acupuncture, tailored to their syndrome differentiation (e.g., heat-clearing, detoxifying, or dampness-resolving therapies).

Western Medicine Group

Description:

Intervention: Patients receive only standard Western medical care, which may include antipyretics (e.g., acetaminophen), NSAIDs for pain, and supportive treatments (e.g., hydration).

Integrated Therapy Group

Description:

Intervention: Patients receive both Chinese and Western treatments.