Receptive Music Interventions During Intradermal Testing in Children

Hilal Gungor

Status: Completed

Conditions: Child; Pain Management; Anxiety; Music Therapy; Skin Tests

Treatments: Behavioral: Receptive Music Therapy - Traditional Turkish Music; Behavioral: Receptive Music Therapy - Solfeggio Frequencies

Study type: Interventional

Funder types: Other

Identifiers

NCT07013669

2025-276166482

Details and patient eligibility

About

The study summary and design were to assess procedural anxiety and stress in parents and pain perception in children during intradermal testing. Music medicine was incorporated into the study design as a nonpharmacological intervention. Two distinct auditory modalities were used: solfeggio frequencies-174 Hz, 285 Hz, 396 Hz, and 528 Hz-which have been suggested to interact with the human energy field through resonance-based mechanisms, and Turkish classical musical modes (makams), such as Rast, Hicaz, Uşşak, Neva, and Saba, which are modal systems that include microtonal intervals and follow specific melodic progressions that are often associated with different emotional and spiritual effects as well as sensory and emotional regulation potential.

Enrollment: 120 patients

Sex: All

Ages: 2 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Children aged between 2 and 17 years
2. Referred to the Pediatric Allergy Clinic for evaluation of suspected drug hypersensitivity reactions
3. Accompanied by a parent or legal guardian willing to participate
4. Written informed consent obtained from parents or legal guardians

Exclusion criteria

1. Known neurological, psychiatric, or developmental disorders in the child
2. Use of sedatives or analgesic medications within 24 hours prior to testing
3. Hearing impairment or auditory processing disorders in the child4.Non-consent or withdrawal of consent by parent or guardian
4. Inability of the parent to complete anxiety assessments (e.g., due to language or cognitive barriers)

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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120 participants in 3 patient groups

Control Group

No Intervention group

Description:

Participants undergo standard intradermal testing (IDT) without any additional auditory intervention

Solfeggio Music Intervention

Experimental group

Description:

Participants receive receptive music therapy using Solfeggio frequencies (174 Hz, 285 Hz, 396 Hz, and 528 Hz) during the IDT procedure. Music starts five minutes before and continues throughout the procedure

Treatment:

Behavioral: Receptive Music Therapy - Solfeggio Frequencies

Traditional Turkish Music Intervention

Experimental group

Description:

Participants receive receptive music therapy using selected Traditional Turkish Music modes (makams), including Rast, Hicaz, Uşşak, Neva, and Saba, during the IDT procedure. Music starts five minutes before and continues throughout the procedure

Treatment:

Behavioral: Receptive Music Therapy - Traditional Turkish Music