Reciprocal Imitation Training and Musical Rhythm Sensitivity in Autistic Toddlers

Vanderbilt University Medical Center

Status: Enrolling

Conditions: Autism Spectrum Disorder; Autism

Treatments: Behavioral: Reciprocal Imitation Training; Behavioral: music-enhanced Reciprocal Imitation Training

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT05880225

MH123029

Details and patient eligibility

About

The primary goal of this study is to examine rhythm sensitivity as a predictor of response to naturalistic developmental behavioral intervention (NDBIs) in autistic toddlers. Toddlers receive either Reciprocal Imitation Training (RIT), an evidence-based NDBI that supports children's imitation and social communication skills, or a music-enhanced version of RIT. Throughout their participation in the intervention, toddlers will complete study procedures of viewing naturalistic videos of infant-directed singing and other social scenes while eye gaze data is collected.

Full description

Social communication makes use of predictable, rhythmic behaviors and children are sensitive to the rhythm of social interaction from infancy. The goal of the current study is to investigate if social rhythm sensitivity, measured via children' entrained eye-looking when viewing videos of infant-directed singing, predicts autistic toddlers' response to naturalistic developmental behavioral intervention (NDBI). Following eligibility testing and baseline assessments, children are randomized to receive either 30 sessions of Reciprocal Imitation Training (RIT), an NDBI that uses evidence-based strategies to support children's imitation and social communication development, or a music-enhanced version of RIT that embeds music and rhythm within the RIT platform (meRIT). Children's imitation skills are assessed before and after the intervention programs. Children's rhythm sensitivity is assessed via repeated eye-tracking sessions throughout baseline, intervention, and two-weeks after the intervention ends.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 36 months old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosis of autism / autism spectrum disorder
• 18-36 months of age

Exclusion criteria

• Major hearing or visual impairment (e.g., congenital nystagmus), seizure disorder, genetic syndromes, or gestational age <=34 weeks.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

Reciprocal Imitation Training (RIT)

Active Comparator group

Description:

Children (n=20) receive 30 sessions of Reciprocal Imitation Training (RIT), delivered in 40-60 minute sessions 2-3 times/week.

Treatment:

Behavioral: Reciprocal Imitation Training

Music-Enhanced Reciprocal Imitation Training (meRIT)

Experimental group

Description:

Children (n=20) receive 30 sessions of music-enhanced Reciprocal Imitation Training (meRIT), delivered in 40-60 minute sessions 2-3 times/week.

Treatment:

Behavioral: music-enhanced Reciprocal Imitation Training