Recirculation, Oxygenator Blood Volume and Cardiac Output Measurements During Extracorporeal Membrane Oxygenation

Transonic Systems

Status: Terminated

Conditions: Recirculation; Venovenous Extracorporeal Membrane Oxygenation; Cardiac Output; Oxygenator Blood Volume; Venoarterial Extracorporeal Membrane Oxygenation

Study type: Observational

Funder types: Industry; NIH

Identifiers

NCT00920569

TSI-G-HCE101-2A-H

1R43HL082022-01 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

This study is to test the usefulness of ultrasound dilution measurements in patients on extracorporeal membrane oxygenation. Measurements may include; efficiency of support (recirculation), amount of clotting in the oxygenator (oxygenator blood volume), and how well the heart is working (cardiac output). At the present time there are no devices available to perform these functions.

Full description

At the present time there are no devices available to measure recirculation, oxygenator blood volume and cardiac output in patients on extracorporeal membrane oxygenation. The study uses an external monitor, laptop computer, clamp on flowsensors and ultrasound dilution technology to measure blood flow. Measurements are made by injecting 0.5 - 1 ml/kg of sterile isotonic saline into the patient's extracorporeal circuit. The subject will be monitored throughout the measurements. The measurements will be coordinated with the regular care of the extracorporeal circuit.

Enrollment: 8 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Neonatal, pediatric or adult patients receiving venoarterial or venovenous extracorporeal membrane oxygenation.

Exclusion criteria

• Patients not receiving venoarterial or venovenous extracorporeal membrane oxygenation.