Recombinant BNP on Heart and Renal Function in Acute Heart Failure

Shanghai Jiao Tong University

Status and phase: Unknown; Phase 2

Conditions: Acute Heart Failure; Acute Renal Failure

Treatments: Drug: standard of care; Drug: rhBNP

Study type: Interventional

Funder types: Other

Identifiers

NCT01625403

SHCHESTCCU01

Details and patient eligibility

About

The purpose of this study is to evaluate the efficacy and safety of recombinant human B-type natriuretic peptide (rhBNP) on heart and renal function in patients with acute decompensated heart failure (ADHF) and acute renal injury (AKI).

Full description

Patients with acute decompensated heart failure (ADHF) and acute renal injury (AKI) will be randomized to receive standard of care with or without additional rhBNP.

Clinical heart function, LVEF, SCr, GFR and other laboratory parameters will be evaluated.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• acute heart failure with acute renal injury

Exclusion criteria

• not tolerate to rhBNP

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

rhBNP treated

Experimental group

Description:

standard of care with rhBNP

Treatment:

Drug: rhBNP

standard of care

Active Comparator group

Description:

standard of care

Treatment:

Drug: standard of care