Recombinant Human Thrombopoietin for Mobilization of Peripheral Blood Progenitor Cells for Autologous Transplantation

H

Hongnan Mo

Status and phase

Unknown
Phase 2
Phase 1

Conditions

Hematopoietic Stem Cell Mobilization
Hematopoietic Stem Cell Transplantation
Thrombocytopoietin

Treatments

Drug: Recombinant Human Thrombopoietin

Study type

Interventional

Funder types

Other

Identifiers

NCT03014102
LC2016B03

Details and patient eligibility

About

The purpose of this study is to determine whether recombinant human thrombopoietin are effective in peripheral blood progenitor cells mobilization for autologous transplantation.

Enrollment

50 estimated patients

Sex

All

Ages

18 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • a histologically confirmed diagnosis of Hodgkin's disease, non-Hodgkin's lymphoma, or selected high-risk solid tumors that are planned to receive autologous peripheral blood progenitor cell transplantation
  • Eastern Cooperative Oncology Group performance status of 0 - 2.

Exclusion criteria

  • abnormal liver function (aminotransferase or bilirubin levels 2 times upper limit of normal), leukopenia (white blood cell count 3000/L), or a history of platelet or other disorders associated with a bleeding diathesis
  • a history of thromboembolic disease, coronary heart disease,stroke, arrhythmias, central nervous system metastases,or other organ system diseases or abnormalities that might predispose individuals to treatment-related complications

Trial design

50 participants in 2 patient groups

TPOqd
Experimental group
Description:
Recombinant Human Thrombopoietin 300U/kg/d ih quaque die, day-3/-2/-1 before mobilization
Treatment:
Drug: Recombinant Human Thrombopoietin
TPOqod
Active Comparator group
Description:
Recombinant Human Thrombopoietin 300U/kg/d ih qua altera die, day-3/-1/+2 before mobilization
Treatment:
Drug: Recombinant Human Thrombopoietin

Trial contacts and locations

0

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Central trial contact

Hongnan Mo, MD

Data sourced from clinicaltrials.gov

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